Immunogenicity of NSDV GP38 and the Role of Furin in Glycoprotein Processing
We are proud to highlight a new peer-reviewed publication by Kerstin Fischer and colleagues at the Friedrich-Loeffler-Institut (FLI), supported by the CCHFVacim project and funded by the European Health and Digital Executive Agency (HaDEA).
🔬 The study explores the presence and immunogenicity of the GP38 glycoprotein in sheep infected with Nairobi sheep disease virus (NSDV) — a virus genetically related to Crimean-Congo hemorrhagic fever virus (CCHFV). The research provides key evidence that GP38 is expressed and immunogenic in NSDV-infected animals, and investigates the proteolytic role of the enzyme furin in this process.
💡 These findings contribute to a better understanding of CCHFV-related orthonairoviruses, and open promising avenues for the development of serological tools and cross-species models of pathogenesis.
📄 Reference:
Bost C., Tomaz F., Schmacke L. C. et al. (2025)
Immunogenicity of NSDV GP38 and the role of furin in GP38 proteolytic processing. Journal of Virology.
