Developing both prophylactic 
and therapeutic effective 
countermeasures

Crimean Congo Haemorrhagic Fever 
Vaccine & Immunotherapy

The CCHFVACIM project aims to address the serious public health threat posed by Crimean Congo Haemorrhagic Fever Virus (CCHFV), a tick-borne zoonotic virus that causes fatal epidemics in humans. This is one of the most threatening vector-borne pathogens, widely distributed, including on the European continent. Currently, there are no preventive or effective therapeutic measures available against CCHFV, which is listed as a key priority in the WHO’s R&D Blueprint list of infectious agents with epidemic or pandemic potential.

Deep structural biology studies on viral glycoproteins and investigation of the immunogenicity of the viral antigens will be combined with optimisation of a mRNA vaccine candidate against the virus and characterisation of the resulting protective immunity, as well as with the development of immuno-therapeutic monoclonal antibodies (mAbs) based on CCHFV’s antigenic targets.


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News

  • Project milestones & first achievements

    CCHFVACIM reaches key milestones in its first reporting period. The CCHFVACIM project has made significant progress during its first reporting period (January 2024 – June 2025), laying strong foundations for the development of innovative vaccines and immunotherapies against Crimean-Congo Haemorrhagic Fever (CCHF). Among the key achievements, the consortium successfully designed and evaluated multiple mRNA-based vaccine…

  • New Publication!

    Our team developed a rapid, versatile “plug-and-play” pseudotyped virus neutralisation assay that allows scientists to measure immune responses to several dangerous bunyaviruses without needing high-containment (BSL-3/4) facilities.This is a major step forward because: 🔍 Why it matters for CCHFVACIMThe CCHFVACIM project aims to advance vaccines and medical countermeasures against CCHFV. One of our biggest bottlenecks…

  • 🦠 Crimean-Congo Hemorrhagic Fever in Greece: A Rare but Serious Case

    Greek health authorities have reported a confirmed case of Crimean-Congo hemorrhagic fever (CCHF) in a 71-year-old man. Initially presenting with fever, myalgia, and gastrointestinal symptoms, his condition evolved rapidly to include neurological signs and hemorrhages, leading to his death shortly after diagnosis. 🇬🇷 This is Greece’s first CCHF case in 2025 and only the second…