Developing both prophylactic 
and therapeutic effective 
countermeasures

Crimean Congo Haemorrhagic Fever 
Vaccine & Immunotherapy

The CCHFVACIM project aims to address the serious public health threat posed by Crimean Congo Haemorrhagic Fever Virus (CCHFV), a tick-borne zoonotic virus that causes fatal epidemics in humans. This is one of the most threatening vector-borne pathogens, widely distributed, including on the European continent. Currently, there are no preventive or effective therapeutic measures available against CCHFV, which is listed as a key priority in the WHO’s R&D Blueprint list of infectious agents with epidemic or pandemic potential.

Deep structural biology studies on viral glycoproteins and investigation of the immunogenicity of the viral antigens will be combined with optimisation of a mRNA vaccine candidate against the virus and characterisation of the resulting protective immunity, as well as with the development of immuno-therapeutic monoclonal antibodies (mAbs) based on CCHFV’s antigenic targets.


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News

  • New CCHFVACIM Brochure Available!

    Discover our new A4 brochure (two-sided) presenting the CCHFVACIM project, its mission, partners, and scientific ambition.It provides a clear overview of how the consortium is advancing vaccines and immunotherapies against Crimean-Congo haemorrhagic fever, through a One Health-driven, interdisciplinary approach. 👉 [Download the brochure here]

  • 🌍 Launch of the CCHFVACIM Scientific Watch

    With the Scientific Watch series, CCHFVACIM brings you timely updates on research, outbreaks, and global health developments related to Crimean-Congo haemorrhagic fever (CCHF) and other high-consequence viruses. Our aim is to highlight scientific advances, surveillance findings, and policy-relevant insights that connect directly to the mission of CCHFVACIM: strengthening preparedness through better vaccines, therapeutics, and diagnostics.…

  • New Publication!

    Immunogenicity of NSDV GP38 and the Role of Furin in Glycoprotein Processing We are proud to highlight a new peer-reviewed publication by Kerstin Fischer and colleagues at the Friedrich-Loeffler-Institut (FLI), supported by the CCHFVacim project and funded by the European Health and Digital Executive Agency (HaDEA). 🔬 The study explores the presence and immunogenicity of the GP38 glycoprotein in sheep…